Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.

Stroke stays a number one reason behind incapacity in america. Regardless of latest advances, interventions to scale back injury and improve restoration after stroke are missing. P2X4R, a receptor for adenosine triphosphate (ATP), regulates activation of myeloid immune cells (infiltrating monocytes/macrophages and brain-resident microglia) after stroke damage.

Nonetheless, over-stimulation of P2X4Rs on account of extreme ATP launch from dying or broken neuronal cells can contribute to ischemic damage. Subsequently, we pharmacologically inhibited P2X4R to restrict the over-stimulated myeloid cell immune response and enhance each acute and power stroke restoration. We subjected 8-12-week-old female and male wild sort mice to a 60 min proper center cerebral artery occlusion (MCAo) adopted by Three or 30 days of reperfusion.

We carried out histological, RNA sequencing, behavioral (sensorimotor, nervousness, and depressive), and biochemical (Evans blue dye extravasation, western blot, quantitative PCR, and circulation cytometry) analyses to find out the acute (Three days after MCAo) and power (30 days after MCAo) results of P2X4R antagonist 5-BDBD (1 mg/kg P.O. every day x Three days submit four h of MCAo) remedy.

5-BDBD remedy considerably (p < .05) diminished infarct quantity, neurological deficit (ND) rating, ranges of cytokine interleukin-1 beta (IL-1β) and blood mind barrier (BBB) permeability within the 3-day group.

EIF3CL Recombinant Protein (Human)
RP056388 100 ug Ask for price

EIF3CL (N-term) Rabbit pAb
E2618440 100ul
EUR 225
Description: Available in various conjugation types.

EIF3CL (untagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL)
SC316845 10 µg Ask for price

EIF3CL ORF Vector (Human) (pORF)
ORF018797 1.0 ug DNA
EUR 486

Human EIF3CL knockout cell line
ABC-KH4695 1 vial Ask for price
Description: Human EIF3CL knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

EIF3CL (GFP-tagged) - Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL)
RG223143 10 µg Ask for price

Human EIF3CL knockdown cell line
ABC-KD4695 1 vial Ask for price
Description: Human EIF3CL knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

EIF3CL (Myc-DDK-tagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL)
RC223143 10 µg Ask for price

EIF3CL 3'UTR GFP Stable Cell Line
TU056731 1.0 ml
EUR 1672.8

EIF3CL sgRNA CRISPR Lentivector set (Human)
K0667301 3 x 1.0 ug
EUR 406.8

EIF3CL Protein Vector (Human) (pPM-C-HA)
PV075187 500 ng
EUR 973.2

EIF3CL Protein Vector (Human) (pPB-C-His)
PV075185 500 ng
EUR 973.2

EIF3CL Protein Vector (Human) (pPB-N-His)
PV075186 500 ng
EUR 973.2

EIF3CL Protein Vector (Human) (pPM-C-His)
PV075188 500 ng
EUR 973.2

EIF3CL 3'UTR Luciferase Stable Cell Line
TU006731 1.0 ml
EUR 1672.8

Lenti-ORF clone of EIF3CL (mGFP-tagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL)
RC223143L4 10 µg Ask for price

Lenti-ORF clone of EIF3CL (Myc-DDK-tagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL)
RC223143L3 10 µg Ask for price

Lenti ORF particles, EIF3CL (mGFP-tagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL), 200ul, >10^7 TU/mL
RC223143L4V 200 µl Ask for price

EIF3CL sgRNA CRISPR Lentivector (Human) (Target 1)
K0667302 1.0 ug DNA
EUR 184.8

EIF3CL sgRNA CRISPR Lentivector (Human) (Target 2)
K0667303 1.0 ug DNA
EUR 184.8

EIF3CL sgRNA CRISPR Lentivector (Human) (Target 3)
K0667304 1.0 ug DNA
EUR 184.8

Lenti ORF particles, EIF3CL (Myc-DDK-tagged)-Human eukaryotic translation initiation factor 3, subunit C-like (EIF3CL), 200ul, >10^7 TU/mL
RC223143L3V 200 µl Ask for price

OAAB08888-400UL - EIF3CL Antibody - N-terminal region
OAAB08888-400UL 400ul
EUR 389

EIF3CL (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
SR319023 2 nmol Ask for price

EIF3CL sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K0667305 3 x 1.0 ug
EUR 451.2

EIF3CL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0667306 1.0 ug DNA
EUR 200.4

EIF3CL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K0667307 1.0 ug DNA
EUR 200.4

EIF3CL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K0667308 1.0 ug DNA
EUR 200.4

EIF3CL - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector
TL321053 5 µg/vial Ask for price

EIF3CL - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector
TR321053 5 µg/vial Ask for price

Human Eukaryotic translation initiation factor 3 subunit C-like protein (EIF3CL) ELISA Kit
abx521802-96tests 96 tests
EUR 687.5

3`UTR clone of eukaryotic translation initiation factor 3 subunit C-like (EIF3CL) for miRNA target validation
SC202570 10 µg Ask for price

EIF3CL - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
TL321053V 500 ul each Ask for price

Eif3c/ Rat Eif3c ELISA Kit
ELI-09630r 96 Tests
EUR 1063.2

EIF2C2
CSB-CL891731HU1 10 μg plasmid + 200μl Glycerol Ask for price

EIF2C2
CSB-CL891731HU2 10 μg plasmid + 200μl Glycerol Ask for price

EIF2C3
CSB-CL875700HU 10 μg plasmid + 200μl Glycerol Ask for price

EIF2C3 Rabbit mAb
59065 100ul
EUR 339

EIF2C1 Peptide
45-525P 0.1 mg
EUR 405.6
Description: EIF2C1 Peptide

EIF2C3 Rabbit pAb
E2381362 100ul
EUR 225
Description: Available in various conjugation types.

EIF2C2 Rabbit pAb
E2506802 100ul
EUR 225
Description: Available in various conjugation types.

EIF2C2 Rabbit pAb
E2510968 100ul
EUR 225
Description: Available in various conjugation types.

eIF2C3 Rabbit mAb
A19819 50μL
EUR 778.7
Description: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HTRA2 (O43464).

Eif2c4 (untagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), (10 ug)
RN215671 10 µg Ask for price

Eif2c2 (untagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), (10 ug)
RN210245 10 µg Ask for price

EIF2C1 Antibody
39951-100ul 100ul
EUR 468

EIF2C3 Antibody
39952-100ul 100ul
EUR 468

EIF2C3 Antibody
DF9508 200ul
EUR 420

EIF2C3 Antibody
DF9508-100ul 100ul
EUR 280

EIF2C3 Antibody
DF9508-200ul 200ul
EUR 350

EIF2C1 antibody
E39-10769 100ug/100ul
EUR 225
Description: Available in various conjugation types.

EIF2C1 Antibody
E301712b 100ug/200ul
EUR 275
Description: Available in various conjugation types.

EIF2C3 Antibody
E301713 200ul
EUR 275
Description: Available in various conjugation types.

EIF2C2 Antibody
E312331 200ul
EUR 275
Description: Available in various conjugation types.

EIF2C3 Antibody
E19-9508-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

EIF2C3 Antibody
E19-9508-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

EIF2C2 antibody
70R-17042 50 ul
EUR 289
Description: Rabbit polyclonal EIF2C2 antibody

EIF2C1 antibody
70R-21524 50 ul
EUR 289
Description: Rabbit polyclonal EIF2C1 antibody

EIF2C3 antibody
70R-2539 50 ug
EUR 467
Description: Rabbit polyclonal EIF2C3 antibody raised against the N terminal of EIF2C3

EIF2C4 antibody
70R-3041 50 ug
EUR 467
Description: Rabbit polyclonal EIF2C4 antibody raised against the middle region of EIF2C4

EIF2C1 antibody
70R-3471 50 ug
EUR 467
Description: Rabbit polyclonal EIF2C1 antibody raised against the N terminal of EIF2C1

Eif2c3 antibody
70R-9606 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Eif2c3 antibody

EIF2C3 Antibody
ABD9508 100 ug
EUR 525.6

EIF2C1 Antibody
GWB-MT589D 50ug Ask for price

EIF2C4 Antibody
GWB-MV390C 50ug Ask for price

Eif2c3 Antibody
GWB-MV397A 50ug Ask for price

EIF2C3 Antibody
GWB-MV398B 50ug Ask for price

EIF2C1 ELISA KIT|Human
EF009333 96 Tests
EUR 826.8

EIF2C3 ELISA KIT|Human
EF009334 96 Tests
EUR 826.8

EIF2C3/ Argonaute 3
E8ET1701-26 100ul
EUR 275
Description: Available in various conjugation types.

Lenti ORF particles, Eif2c4 (GFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), 200ul, >10^7 TU/mL
RR215671L4V 200 µl Ask for price

Lenti ORF particles, Eif2c2 (GFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200ul, >10^7 TU/mL
RR210245L4V 200 µl Ask for price

Eif2c4 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), (10 ug)
RR215671 10 µg Ask for price

Eif2c2 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), (10 ug)
RR210245 10 µg Ask for price

Eif2c1 ORF Vector (Rat) (pORF)
ORF066440 1.0 ug DNA
EUR 607.2

Eif2c2 ORF Vector (Rat) (pORF)
ORF066441 1.0 ug DNA
EUR 607.2

Eif2c4 ORF Vector (Rat) (pORF)
ORF066442 1.0 ug DNA
EUR 607.2

Lenti ORF particles, Eif2c4 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), 200ul, >10^7 TU/mL
RR215671L3V 200 µl Ask for price

Lenti ORF particles, Eif2c2 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), 200ul, >10^7 TU/mL
RR210245L3V 200 µl Ask for price

EIF2C2 cloning plasmid
CSB-CL891731HU1-10ug 10ug
EUR 722.4
Description: A cloning plasmid for the EIF2C2 gene.

EIF2C2 cloning plasmid
CSB-CL891731HU2-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the EIF2C2 gene.

EIF2C3 cloning plasmid
CSB-CL875700HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the EIF2C3 gene.

EIF2C1 ORF Vector (Human) (pORF)
ORF018785 1.0 ug DNA
EUR 486

EIF2C4 ORF Vector (Human) (pORF)
ORF018786 1.0 ug DNA
EUR 486

Eif2c1 ORF Vector (Mouse) (pORF)
ORF043747 1.0 ug DNA
EUR 607.2

Eif2c2 ORF Vector (Mouse) (pORF)
ORF043748 1.0 ug DNA
EUR 607.2

Eif2c3 ORF Vector (Mouse) (pORF)
ORF043749 1.0 ug DNA
EUR 607.2

Eif2c4 ORF Vector (Mouse) (pORF)
ORF043750 1.0 ug DNA
EUR 607.2

EIF2C2 ORF Vector (Human) (pORF)
ORF003459 1.0 ug DNA
EUR 114

EIF2C2 ORF Vector (Human) (pORF)
ORF003460 1.0 ug DNA
EUR 114

EIF2C3 ORF Vector (Human) (pORF)
ORF003461 1.0 ug DNA
EUR 114

EIF2C1 3'UTR GFP Stable Cell Line
TU056714 1.0 ml
EUR 2799.6

EIF2C2 3'UTR GFP Stable Cell Line
TU056715 1.0 ml
EUR 1825.2

EIF2C3 3'UTR GFP Stable Cell Line
TU056716 1.0 ml
EUR 1672.8

EIF2C4 3'UTR GFP Stable Cell Line
TU056717 1.0 ml
EUR 2799.6

Eif2c1 3'UTR GFP Stable Cell Line
TU253872 1.0 ml Ask for price

Eif2c2 3'UTR GFP Stable Cell Line
TU253873 1.0 ml Ask for price

Eif2c3 3'UTR GFP Stable Cell Line
TU253874 1.0 ml Ask for price

Eif2c4 3'UTR GFP Stable Cell Line
TU253875 1.0 ml Ask for price

Eif2c1 3'UTR GFP Stable Cell Line
TU155704 1.0 ml Ask for price

Eif2c2 3'UTR GFP Stable Cell Line
TU155705 1.0 ml Ask for price

Eif2c3 3'UTR GFP Stable Cell Line
TU155706 1.0 ml Ask for price

Eif2c4 3'UTR GFP Stable Cell Line
TU155707 1.0 ml Ask for price

Lenti ORF clone of Eif2c4 (mGFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), (10 ug)
RR215671L4 10 µg Ask for price

Lenti ORF clone of Eif2c2 (mGFP-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), (10 ug)
RR210245L4 10 µg Ask for price

EIF2C4 Blocking Peptide
33R-1952 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EIF2C4 antibody, catalog no. 70R-3041

EIF2C3 Blocking Peptide
33R-5810 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EIF2C3 antibody, catalog no. 70R-2539

EIF2C1 Blocking Peptide
33R-5890 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EIF2C1 antibody, catalog no. 70R-3471

Eif2c3 Blocking Peptide
33R-9576 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Eif2c3 antibody, catalog no. 70R-9606

EIF2C3 Blocking Peptide
DF9508-BP 1mg
EUR 234

Lenti ORF clone of Eif2c4 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 4 (Eif2c4), (10 ug)
RR215671L3 10 µg Ask for price

Lenti ORF clone of Eif2c2 (Myc-DDK-tagged ORF) - Rat eukaryotic translation initiation factor 2C, 2 (Eif2c2), (10 ug)
RR210245L3 10 µg Ask for price

Anti-Ago2/eIF2C2 Antibody
PB9978 100ug/vial
EUR 352.8

EIF3C
CSB-CL857867HU 10 μg plasmid + 200μl Glycerol Ask for price

EIF2C3/ Argonaute 3 Antibody
49234 100ul
EUR 499

EIF2C3/ Argonaute 3 Antibody
49234-100ul 100ul
EUR 399.6

EIF2C3/ Argonaute 3 Antibody
49234-50ul 50ul
EUR 286.8

EIF2C2 Polyclonal Antibody
30692 100ul
EUR 439

EIF2C2 Polyclonal Antibody
30692-100ul 100ul
EUR 302.4

EIF2C2 Polyclonal Antibody
30692-50ul 50ul
EUR 224.4

EIF2C2 Polyclonal Antibody
30735 100ul
EUR 439

EIF2C2 Polyclonal Antibody
30735-100ul 100ul
EUR 302.4

EIF2C2 Polyclonal Antibody
30735-50ul 50ul
EUR 224.4

EIF2C1-Specific Antibody
abx232697-100ug 100 ug
EUR 577.2

EIF2C3-Specific Antibody
abx232698-100ug 100 ug
EUR 577.2

EIF2C2 Polyclonal Antibody
E96802a 100ul
EUR 225
Description: Available in various conjugation types.

EIF2C1 Protein Vector (Rat) (pPM-C-HA)
PV265760 500 ng
EUR 1429.2

EIF2C2 Protein Vector (Rat) (pPM-C-HA)
PV265764 500 ng
EUR 1399.2

EIF2C4 Protein Vector (Rat) (pPM-C-HA)
PV265768 500 ng
EUR 723.6

EIF2C2 Polyclonal Antibody
A72892 50 μl
EUR 408

EIF2C2 Polyclonal Antibody
A72893 50 μl
EUR 408

EIF2C1-Specific Antibody
abx232697-100g 100 µg
EUR 350

EIF2C2 ELISA Kit (Bovine) (OKEH03983)
OKEH03983 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6 pg/mL

EIF2C1 Protein Vector (Rat) (pPB-C-His)
PV265758 500 ng
EUR 1429.2

EIF2C1 Protein Vector (Rat) (pPB-N-His)
PV265759 500 ng
EUR 1429.2

EIF2C1 Protein Vector (Rat) (pPM-C-His)
PV265761 500 ng
EUR 1429.2

EIF2C2 Protein Vector (Rat) (pPB-C-His)
PV265762 500 ng
EUR 1399.2

EIF2C2 Protein Vector (Rat) (pPB-N-His)
PV265763 500 ng
EUR 1399.2

EIF2C2 Protein Vector (Rat) (pPM-C-His)
PV265765 500 ng
EUR 1399.2

EIF2C4 Protein Vector (Rat) (pPB-C-His)
PV265766 500 ng
EUR 723.6

EIF2C4 Protein Vector (Rat) (pPB-N-His)
PV265767 500 ng
EUR 723.6

EIF2C4 Protein Vector (Rat) (pPM-C-His)
PV265769 500 ng
EUR 723.6

Human Protein argonaute-2 (EIF2C2)
1-CSB-EP891731HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Protein argonaute-2(EIF2C2) ,partial expressed in E.coli

anti- EIF2C1-Specific antibody
FNab02697 100µg
EUR 606.3
Description: Antibody raised against EIF2C1-Specific

anti- EIF2C3-Specific antibody
FNab02698 100µg
EUR 606.3
Description: Antibody raised against EIF2C3-Specific

EIF2C2 Protein Vector (Human) (pPM-C-HA)
PV013835 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPM-C-HA)
PV013839 500 ng
EUR 394.8

EIF2C3 Protein Vector (Human) (pPM-C-HA)
PV013843 500 ng
EUR 394.8

EIF2C1 Protein Vector (Human) (pPM-C-HA)
PV075139 500 ng
EUR 973.2

EIF2C4 Protein Vector (Human) (pPM-C-HA)
PV075143 500 ng
EUR 973.2

EIF2C1 Protein Vector (Mouse) (pPM-C-HA)
PV174988 500 ng
EUR 1278

EIF2C2 Protein Vector (Mouse) (pPM-C-HA)
PV174992 500 ng
EUR 1278

EIF2C3 Protein Vector (Mouse) (pPM-C-HA)
PV174996 500 ng
EUR 1278

EIF2C4 Protein Vector (Mouse) (pPM-C-HA)
PV175000 500 ng
EUR 1278

AGO3 Antibody / Argonaute-3 / eIF2C3
V9391-100UG 100ug
EUR 349.3
Description: This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as Argonaute RISC catalytic component 3. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target complementarity.

AGO3 Antibody / Argonaute-3 / eIF2C3
V9391-20UG 20ug
EUR 153.3
Description: This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as Argonaute RISC catalytic component 3. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target complementarity.

AGO3 Antibody / Argonaute-3 / eIF2C3
V9391SAF-100UG 100ug
EUR 349.3
Description: This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as Argonaute RISC catalytic component 3. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target complementarity.

EIF3C siRNA
20-abx915165
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  • 15 nmol
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EIF3C siRNA
20-abx915166
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  • 15 nmol
  • 30 nmol

EIF3C siRNA
20-abx901680
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  • 15 nmol
  • 30 nmol

Rat Protein argonaute- 2, Eif2c2 ELISA KIT
ELI-24574r 96 Tests
EUR 1063.2

EIF2C2 Protein Vector (Human) (pPB-C-His)
PV013833 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPB-N-His)
PV013834 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPM-C-His)
PV013836 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPB-C-His)
PV013837 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPB-N-His)
PV013838 500 ng
EUR 394.8

EIF2C2 Protein Vector (Human) (pPM-C-His)
PV013840 500 ng
EUR 394.8

EIF2C3 Protein Vector (Human) (pPB-C-His)
PV013841 500 ng
EUR 394.8

EIF2C3 Protein Vector (Human) (pPB-N-His)
PV013842 500 ng
EUR 394.8

EIF2C3 Protein Vector (Human) (pPM-C-His)
PV013844 500 ng
EUR 394.8

EIF2C1 Protein Vector (Human) (pPB-C-His)
PV075137 500 ng
EUR 973.2

EIF2C1 Protein Vector (Human) (pPB-N-His)
PV075138 500 ng
EUR 973.2

EIF2C1 Protein Vector (Human) (pPM-C-His)
PV075140 500 ng
EUR 973.2

EIF2C4 Protein Vector (Human) (pPB-C-His)
PV075141 500 ng
EUR 973.2

EIF2C4 Protein Vector (Human) (pPB-N-His)
PV075142 500 ng
EUR 973.2

EIF2C4 Protein Vector (Human) (pPM-C-His)
PV075144 500 ng
EUR 973.2

EIF2C4 Protein Vector (Mouse) (pPM-C-His)
PV175001 500 ng
EUR 1278

EIF2C1 Protein Vector (Mouse) (pPB-C-His)
PV174986 500 ng
EUR 1278

EIF2C1 Protein Vector (Mouse) (pPB-N-His)
PV174987 500 ng
EUR 1278

Chronically, 5-BDBD remedy additionally conferred progressive restoration (p < .05) of motor stability and coordination utilizing a rotarod take a look at, in addition to diminished anxiety-like conduct over 30 days. Curiously, depressive-type conduct was not noticed in mice handled with 5-BDBD for Three days. As well as, circulation cytometric evaluation revealed that 5-BDBD remedy decreased the overall variety of infiltrated leukocytes, and amongst these infiltrated leukocytes, pro-inflammatory cells of myeloid origin have been particularly diminished. 5-BDBD remedy diminished the cell floor expression of P2X4R in circulation cytometry-sorted monocytes and microglia with out lowering the overall P2X4R stage in mind tissue.

In abstract, acute P2X4R inhibition protects towards ischemic damage at each acute and power time-points after stroke. Diminished numbers of infiltrating pro-inflammatory myeloid cells, decreased floor P2X4R expression, and diminished BBB disruption are seemingly its mechanism of neuroprotection and neuro-rehabilitation.