Methylglyoxal produces more changes in biochemical and biophysical properties of human IgG under high glucose compared to normal glucose level.

Hyperglycaemia triggers elevated manufacturing of methylglyoxal which may trigger gross modification in proteins’ construction vis-a-vis operate although superior glycation finish merchandise (AGEs). The AGEs might provoke vascular and nonvascular pathologies.

On this examine, we have now examined the biochemical and biophysical modifications in human IgG underneath regular and excessive glucose after introducing methylglyoxal into the assay combination. This non-enzymatic response primarily engaged lysine residues as indicated by TNBS outcomes.

The UV outcomes confirmed hyperchromicity in modified-IgG samples whereas fluorescence knowledge supported AGEs formation in the course of the course of response.

Shift in amide I and amide II band place indicated perturbations in secondary construction. Improve carbonyl content material and reduce in sulfhydryl means that the modification is accompanied by oxidative stress.

All modified-IgG samples confirmed extra thermostability than native IgG; the very best Tm was proven by IgG-high glucose-MGO variant. Outcomes of ANS, Congo pink and Thioflavin T dyes clearly recommend improve in hydrophobic patches and aggregation, respectively. SEM and TEM pictures help aggregates technology in modified-IgG samples.

Methylglyoxal produces more changes in biochemical and biophysical properties of human IgG under high glucose compared to normal glucose level.
Methylglyoxal produces extra modifications in biochemical and biophysical properties of human IgG underneath excessive glucose in comparison with regular glucose degree.

Potential of Human Nucleus Pulposus-Like Cells Derived From Umbilical Wire to Deal with Degenerative Disc Illness.

BACKGROUND
Degenerative disc illness (DDD) is a standard spinal dysfunction that manifests with neck and decrease again ache attributable to the degeneration of intervertebral discs (IVDs). At present, there is no such thing as a remedy to treatment this debilitating ailment.
OBJECTIVE
To analyze the potential of nucleus pulposus (NP)-like cells (NPCs) derived from human umbilical twine mesenchymal stem cells (MSCs) to revive degenerated IVDs utilizing a rabbit DDD mannequin.

EIF2S3 antibody

70R-2892 50 ug
EUR 560.4
Description: Rabbit polyclonal EIF2S3 antibody raised against the N terminal of EIF2S3

EIF2S3 antibody

70R-1058 100 ug
EUR 452.4
Description: Rabbit polyclonal EIF2S3 antibody raised against the N terminal of EIF2S3

EIF2S3 antibody

70R-17045 50 ul
EUR 522
Description: Rabbit polyclonal EIF2S3 antibody

EIF2S3 antibody

70R-36621 100 ug
EUR 418.8
Description: Rabbit Polyclonal EIF2S3 antibody

EIF2S3 Antibody

47253-100ul 100ul
EUR 302.4

EIF2S3 Antibody

1-CSB-PA007528ESR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EIF2S3. Recognizes EIF2S3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EIF2S3 Antibody

1-CSB-PA007528ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against EIF2S3. Recognizes EIF2S3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

EIF2S3 Antibody

1-CSB-PA007528GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against EIF2S3. Recognizes EIF2S3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

EIF2S3 Antibody

E047253 100μg/100μl
EUR 255
Description: Available in various conjugation types.

EIF2S3 Antibody

E306242 100ug/200ul
EUR 275
Description: Available in various conjugation types.

EIF2S3 antibody

E39-02701 100ug/100ul
EUR 225
Description: Available in various conjugation types.

EIF2S3 Antibody

E96581 100ul
EUR 255
Description: Available in various conjugation types.

EIF2S3 Antibody

E93848 100μg
EUR 255
Description: Available in various conjugation types.

EIF2S3 Antibody

CAC10716-100ul 100ul
EUR 314

EIF2S3 Antibody

CAC10716-50ul 50ul
EUR 199.2

EIF2G/EIF2S3 Antibody

DF12974 100ul
EUR 280
Description: Human,Mouse

EIF2G/EIF2S3 Antibody

DF12974-100ul 100ul
EUR 280

EIF2G/EIF2S3 Antibody

DF12974-200ul 200ul
EUR 350

EIF2S3 Rabbit pAb

A3848-100ul 100 ul
EUR 369.6

EIF2S3 Rabbit pAb

A3848-200ul 200 ul
EUR 550.8

EIF2S3 Rabbit pAb

A3848-20ul 20 ul
EUR 219.6

EIF2S3 Rabbit pAb

A3848-50ul 50 ul
EUR 267.6

EIF2S3 Rabbit pAb

A6581-100ul 100 ul
EUR 369.6

EIF2S3 Rabbit pAb

A6581-200ul 200 ul
EUR 550.8

EIF2S3 Rabbit pAb

A6581-20ul 20 ul
EUR 219.6

EIF2S3 Rabbit pAb

A6581-50ul 50 ul
EUR 267.6

EIF2S3 Rabbit pAb

E2506581 100ul
EUR 225
Description: Available in various conjugation types.

EIF2S3 Rabbit pAb

E2511275 100ul
EUR 225
Description: Available in various conjugation types.

anti- EIF2S3 antibody

FNab02701 100µg
EUR 658.5
Description: Antibody raised against EIF2S3

EIF2S3 cloning plasmid

CSB-CL007528HU-10ug 10ug
EUR 608.4
Description: A cloning plasmid for the EIF2S3 gene.

EIF2S3 Blocking Peptide

33R-1197 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GRM6 antibody, catalog no. 70R-9576

EIF2S3 Blocking Peptide

33R-4841 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EIF2S3 antibody, catalog no. 70R-1058

EIF2S3 Blocking Peptide

DF12974-BP 1mg
EUR 234

EIF2S3 Conjugated Antibody

C47253 100ul
EUR 476.4

EIF2S3 ELISA KIT|Human

EF009337 96 Tests
EUR 826.8

Human EIF2S3 ELISA KIT

ELI-20270h 96 Tests
EUR 988.8

Bovine EIF2S3 ELISA KIT

ELI-48207b 96 Tests
EUR 1113.6

Chicken EIF2S3 ELISA KIT

ELI-21435c 96 Tests
EUR 1113.6

Human EIF2S3 shRNA Plasmid

20-abx951362
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

EIF2S3 Recombinant Protein (Human)

RP010393 100 ug Ask for price

EIF2S3 ORF Vector (Human) (pORF)

ORF003465 1.0 ug DNA
EUR 114

Human EIF2S3 Protein Lysate 20ug

IHUEIF2S3PLLY20UG each
EUR 213
Description: Human EIF2S3 Protein Lysate 20ug

EIF2S3 3'UTR GFP Stable Cell Line

TU056727 1.0 ml
EUR 1672.8

EIF2S3 sgRNA CRISPR Lentivector set (Human)

K0666901 3 x 1.0 ug
EUR 406.8

EIF2S3 Protein Vector (Human) (pPM-C-HA)

PV013859 500 ng
EUR 394.8

EIF2S3 Protein Vector (Human) (pPB-C-His)

PV013857 500 ng
EUR 394.8

EIF2S3 Protein Vector (Human) (pPB-N-His)

PV013858 500 ng
EUR 394.8

EIF2S3 Protein Vector (Human) (pPM-C-His)

PV013860 500 ng
EUR 394.8

EIF2S3 3'UTR Luciferase Stable Cell Line

TU006727 1.0 ml
EUR 1672.8

EIF2S3 sgRNA CRISPR Lentivector (Human) (Target 1)

K0666902 1.0 ug DNA
EUR 184.8

EIF2S3 sgRNA CRISPR Lentivector (Human) (Target 2)

K0666903 1.0 ug DNA
EUR 184.8

EIF2S3 sgRNA CRISPR Lentivector (Human) (Target 3)

K0666904 1.0 ug DNA
EUR 184.8

EIF2S3 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV791545 1.0 ug DNA
EUR 379.2

EIF2S3 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV791546 1.0 ug DNA
EUR 379.2

EIF2S3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0666905 3 x 1.0 ug
EUR 451.2

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

abx232701-100ug 100 ug
EUR 610.8

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

20-abx321796
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

20-abx321797
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

20-abx112361
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

abx030059-400ul 400 ul
EUR 627.6

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

abx030059-80l 80 µl
EUR 343.2

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

abx036559-100ug 100 ug
EUR 469.2

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

20-abx006825
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) Antibody

20-abx002795
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Eukaryotic Translation Initiation Factor 2 Subunit 3 (eIF2S3) Antibody

20-abx141883
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

EIF2S3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0666906 1.0 ug DNA
EUR 200.4

EIF2S3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0666907 1.0 ug DNA
EUR 200.4

EIF2S3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0666908 1.0 ug DNA
EUR 200.4

EIF2S3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV791543 1.0 ug DNA
EUR 448.8

EIF2S3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV791544 1.0 ug DNA
EUR 448.8

Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E02E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E02E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E02E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E08E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E08E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E08E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E07E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E07E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E07E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) ELISA Kit

abx387092-96tests 96 tests
EUR 1093.2

Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E03E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E03E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E03E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E01E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E01E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E01E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E06E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E06E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E06E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E04E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E04E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E04E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E09E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E09E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E09E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E05E0374-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E05E0374-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) ELISA kit

E05E0374-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Eukaryotic translation initiation factor 2 subunit 3(EIF2S3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Anti Rat EIF2S3 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot)

IRBARTEIF2S3AP454120UL each
EUR 247
Description: Rabbit Anti Rat EIF2S3 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot)

Rabbit Anti Rat EIF2S3 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot)

IRBARTEIF2S3AP454200UL each
EUR 383
Description: Rabbit Anti Rat EIF2S3 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot)

Eif2s1/ Rat Eif2s1 ELISA Kit

ELI-21433r 96 Tests
EUR 1063.2

EIF3S12 antibody

10R-1356 100 ug
EUR 614.4
Description: Mouse monoclonal EIF3S12 antibody

EIF2S1

ant-059 5µg
EUR 60
Description: Mouse Anti Human Eukaryotic Translation Initiation Factor 2 Subunit 1 Alpha

EIF2S1

pro-845 2µg
EUR 60
Description: Recombinant Human Eukaryotic Translation Initiation Factor 2 Subunit 1 Alpha

EIF2S1 siRNA

20-abx915151
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S1 siRNA

20-abx915152
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S2 siRNA

20-abx915153
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S2 siRNA

20-abx915154
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S1 siRNA

20-abx901677
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S3X siRNA

20-abx915156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S3X siRNA

20-abx915157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S3Y siRNA

20-abx915158
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2S3Y siRNA

20-abx915159
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

EIF2B Antibody (EIF2S2)

R31277 100 ug
EUR 356.15
Description: Eukaryotic translation initiation factor 2 subunit 2, also called EIF2B, is a protein that in humans is encoded by the EIF2S2 gene. This gene belongs to the EIF-2-beta family. Eukaryotic translation initiation factor 2 (EIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF2 complex for another round of initiation.

EIF2A Antibody / EIF2S1

V9190-100UG 100ug
EUR 349.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2b and eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

EIF2A Antibody / EIF2S1

V9190-20UG 20ug
EUR 153.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2b and eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

EIF2A Antibody / EIF2S1

V9190SAF-100UG 100ug
EUR 349.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2b and eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

EIF2A Antibody / EIF2S1

V9225-100UG 100ug
EUR 349.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2band eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

EIF2A Antibody / EIF2S1

V9225-20UG 20ug
EUR 153.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2band eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

EIF2A Antibody / EIF2S1

V9225SAF-100UG 100ug
EUR 349.3
Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2band eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
METHODS
NPCs differentiated from MSCs had been characterised utilizing quantitative real-time reverse transcription polymerase chain response and immunocytochemical evaluation. MSCs and NPCs had been labeled with fluorescent dye, PKH26, and transplanted into degenerated IVDs of a rabbit mannequin of DDD (n = 9 every). Magnetic resonance imaging of the IVDs was carried out earlier than and after IVD degeneration, and following cell transplantation. IVDs had been extracted eight wk post-transplantation and analyzed by varied biochemical, immunohistological, and molecular strategies.
RESULTS
NPC derivatives of MSCs expressed identified NP-specific genes, SOX9, ACAN, COL2, FOXF1, and KRT19. Transplanted cells survived, dispersed, and built-in into the degenerated IVDs. IVDs augmented with NPCs confirmed important enchancment within the histology, cellularity, sulfated glycosaminoglycan and water contents of the NP. As well as, expression of human genes, SOX9, ACAN, COL2, FOXF1, KRT19, PAX6, CA12, and COMP, in addition to proteins, SOX9, ACAN, COL2, and FOXF1, recommend NP biosynthesis resulting from transplantation of NPCs. Primarily based on these outcomes, a molecular mechanism for NP regeneration was proposed.
CONCLUSIONS
The findings of this examine demonstrating feasibility and efficacy of NPCs to regenerate NP ought to spur curiosity for scientific research to deal with DDD utilizing cell remedy.